With their APOEL 2-0 overall victory in the play-off round, Ajax qualified for the Champions League group stage.
The close-range header of Edson Alvarez set up a 2-0 win at Johan Cruijff Arena on Wednesday and captain Dusan Tadic made sure 10 minutes from full-time with a good objective.
After a VAR test at 1-0, Klaas-Jan Huntelaar had his goal ruled out for offside, while moments later Andrija Pavlovic was denied an equalizer by the flag of the assistant at the other end.
The Champions League semi-finalists last season under Erik ten Hag, knocked out PAOK to reach the play-off round and the Eredivisie champions will learn their fate in Thursday’s group stage draw.
Slavia Prague are also in the hat after a second 1-0 victory in their tie against Cluj, Jan Boril scoring a second-half winner for the Czech champions.
Club Brugge complete the line-up after qualifying via a 3-1 aggregate win over Austrian side LASK, who had captain Gernot Trauner sent off in a 2-1 loss on Wednesday.